السبت, نوفمبر 23, 2024
السبت, نوفمبر 23, 2024
Home » الخلايا السرطانية تصد جهاز المناعة بإشارة “لا تلتهمني”

الخلايا السرطانية تصد جهاز المناعة بإشارة “لا تلتهمني”

by admin

يأمل الأطباء أن يؤدي الاكتشاف إلى شفاء سرطاني المبيض والثدي

اندبندنت عربية / فيبي ويستون مراسلة الشؤون العلمية @phoeb0

أفادت دراسة جديدة أن الخلايا السرطانية تُرسل إشارة “لا تلتهمني”، كما سمّاها العلماء، بهدف وقف هجمات جهاز المناعة في الجسم عليها.

وفي العادة، تبتلع الخلايا المناعية الخلايا السرطانية وتدمّرها، لكنّ العلماء اكتشفوا في أبحاث سابقة أن البروتينات الموجودة على السطح الخارجي لبعض الخلايا السرطانية ترسل إلى خلايا في الجهاز المناعي “إشارات” تأمرها بعدم القضاء على خلايا الورم الخبيث.

وتذكيراً، تتمثّل المهمة الأصلية لتلك الإشارات في منع خلايا المناعة من التهام الخلايا السليمة في الجسم. وفي المقابل، يبدو أن إشارات الحماية ليست حكراً على الخلايا السليمة. إذ اكتشف باحثون من كلية الطب في “جامعة ستانفورد” بولاية كاليفورنيا أن الخلايا السرطانية تلجأ إلى الإشارات نفسها للاختباء من جهاز المناعة.

خلال الدراسة، اكتشف الباحثون أن بروتيناً يُسمى “سي دي 24”  يُرسل إشارة أطلقوا عليها إسم “لا تلتهمني” يمنع جهاز المناعة من التهام الخلية التي تصدر منها تلك الإشارة. واستطراداً، قد يفضي ذلك الاكتشاف إلى ابتكار علاج شافٍ لسرطاني المبيض وسرطان الثدي اللذان يصيبان آلاف النساء في المملكة المتحدة سنوياً.

وفي تلك الدراسة عينها، عمل الباحثون على وقف بث إشارة “سي دي 24” من خلايا سرطانية بشرية كانوا قد زرعوها في فئران، ووجدوا أن خلايا المناعة المنوط بها التهام مسببات الأمراض في أجسامنا تمكّنت من مهاجمة الخلايا السرطانية بعد توقف بث تلك الإشارة. ونتيجة لذلك، انخفض نمو الورم السرطاني وطال عمر الفئران، بحسب ما أشار إليه أولئك العلماء في نتائج الدراسة التي نُشرت في مجلة “نايتشر”.

اقرأ المزيد

الشباب عرضة للسرطانات المتّصلة بالبدانة أكثر ممن تجاوزوا سن الـ 45

الخلايا الجذعية تحدث قفزة نوعية في علاج الصلع

وفي أوقات سابقة، بيّن باحثون من الجامعة نفسها أن الخلايا السرطانية تستخدم بروتينات أخرى لحماية نفسها من الخلايا المناعية. يُسمى أحد تلك البروتينات “سي دي 47″، وقد ابتكر العلماء علاجات مضادة له ما زالت قيد التجارب السريرية.

في ذلك الصدد، ذكرت أميرة باركال التي شاركت في الدراسة الأخيرة بوصفها باحثة تحضّر رسالة دكتوراة، إن “علاجات السرطان التي توقف إشارة “سي دي 24” تضرب ذلك “الدرع” الذي يحمي الخلايا السرطانية، ما يمكن خلايا المناعة المسؤولة عن مواجهة الأجسام المؤذية، من ابتلاع خلايا السرطان تماماً”.

وفي المقابل، أوضحت باركال إنّه “يتعيّن إجراء مزيد من الأبحاث لتحديد المرضى الذين قد يستفيدون من العلاجات المضادة لبروتين “سي دي 24”. وذكرت أيضاً أن “سرطاني المبيض وسرطان الثدي من بين أكثر الأمراض النسائية المميتة، وكلاهما عدواني ويصعب علاجه من دون جراحة. لذا، نحن متحمّسون للعلاجات التي ستوفرها نتائج الأبحاث الأخيرة، من أجل بناء استراتيجية جديدة لعلاج هذين النوعين من السرطان، بل ربما القضاء عليهما”.

في سياق متصل، أضاف زميلها الباحث إيرفينغ ويسمان، أستاذ علم الأمراض وعلم الأحياء التطوري ومدير “معهد بيولوجيا الخلايا الجذعية والطب التجديدي” في “جامعة ستانفورد”، أن “أبحاثهم كشفت أن ثمة مرضى يستجيبون عند إعطائهم الأجسام المناعية المضادة لبروتين “سي دي 47” فيما لا يظهر الأثر نفسه عند آخرين. وأدّى ذلك إلى متابعة البحث لمعرفة إذا كان المرضى والخلايا السرطانية غير المستجيبة، لديهم الإشارات البديلة “لا تلتهمني”.

واستناداً إلى ذلك، بدأ الفريق في البحث عن بروتينات موجودة في الخلايا السرطانية أكثر منها في الخلايا السليمة، ووجدوا كميات كبيرة من بروتين “سي دي 24”.

وعندما وضعوا خلايا سرطانية مختلطة مع خلايا مناعية ملتهمة في أطباق المختبر وحجبوا إشارة “لا تلتهمني”، بدأت الخلايا المناعية في “التهام الخلايا السرطانية كما لو أنها في مطعم مفتوح”.

وأضافت باركال أنّ “تصوير الخلايا المناعية الملتهمة بعد إعطاء علاج يوقف إشارة بروتين “سي دي 24″، كشف أن بعضها كان متخماً بالخلايا السرطانية تماماً”.

وأعرب الباحثون عن حماستهم بشأن استجابة سرطاني المبيض والثدي (خصوصاً النوع المقاوم للعلاج الثلاثي) للأدوية التي تعترض إشارة “لا تلتهمني”. ويرجع ذلك أن نوعي السرطان يستعصيان على العلاج، ويعتقد العلماء أن بروتين “سي دي 24” يشكّل “الحاجز الرئيسي الرادع لجهاز المناعة” لدى هذين السرطانين.

في سياق متّصل، ذكرت ريبيكا رينيسون، مديرة الشؤون والخدمات العامة في المنظمة الخيرية “تارغت أوفاريين كانسر” (حرفياً، “استهدف سرطان المبيض”)، إن “ابتكار علاجات أكثر فاعلية لسرطان المبيض خطوة بالغة الأهمية لمكافحة ذلك الداء القاتل. وصلنا إلى علاجات مناعية مهمة واجهت سرطانات اخرى، غير أنها لم تثبت جدواها في سرطان المبيض. في المقابل، يحمل الاكتشاف الأخير أملاً واعداً في مجال علاج السرطان، وإذا أثبتت الأبحاث المقبلة جدارته، فلا شك في أنه سيشكل إنجازاً مهماً”.

© The Independent

المزيد عن: جهاز المناعة/سي دي 24/سي دي 47/سرطان المبيض/سرطان الثدي

 

 

You may also like

97 comments

Inger Duker 7 يوليو، 2020 - 4:14 م

I just want to say I am newbie to blogging and seriously liked your blog site. Most likely I’m going to bookmark your blog post . You surely come with beneficial stories. Thanks a lot for sharing with us your website.

http://www.withapackofpizzaz.com

Reply
can you buy viagra off the shelf 8 يوليو، 2020 - 11:33 م

This internet site is really a walk-through for all of the details you wanted concerning this and didn?t understand who to ask. Peek here, and you?ll absolutely find it.

https://judpharmacy.com/

Reply
CBD Capsules 8 يوليو، 2020 - 11:37 م

I feel like I’m constantly looking for interesting things to read about a variety of subjects, but I manage to include your blog among my reads every day because you have compelling entries that I look forward to. Here’s hoping there’s a lot more amazing material coming!

https://resenhaalvinegra.com.br/veja-7-astros-mundiais-que-quase-fecharam-com-o-botafogo/

Reply
iron screen doors 10 يوليو، 2020 - 5:00 م

Howdy! I know this is kinda off topic however , I’d figured I’d ask. Would you be interested in trading links or maybe guest authoring a blog article or vice-versa? My blog goes over a lot of the same subjects as yours and I feel we could greatly benefit from each other. If you happen to be interested feel free to send me an email. I look forward to hearing from you! Superb blog by the way!

https://youtu.be/f4Sa8t2b-H8

Reply
Tractor Workshop Manuals 10 يوليو، 2020 - 10:00 م

digital cameras are really great because you can shoot and preview the pictures right away;

http://partscatalog.sellload.com

Reply
cbd oil for sale monthly club 13 يوليو، 2020 - 10:49 م

I found your blog site on google and also inspect a few of your early posts. Remain to maintain the very good operate. I simply added up your RSS feed to my MSN Information Reader. Looking for onward to learning more from you in the future!?

https://cbdhempoilsale.us/

Reply
cbd oil 14 يوليو، 2020 - 4:55 م

I am usually to blogging and also i really appreciate your web content. The article has actually peaks my rate of interest. I am mosting likely to bookmark your website as well as keep looking for brand-new info.

http://cbdoil4u.org/

Reply
Tractor Workshop Manuals 15 يوليو، 2020 - 4:53 ص

very good publish, i actually love this web site, carry on it

http://partscatalog.sellload.com

Reply
best cbd pain relief for dogs non oral 15 يوليو، 2020 - 9:27 ص

This truly answered my problem, thank you!

https://cbdoilfordog.org/

Reply
human cbd vs dog cbd 16 يوليو، 2020 - 9:20 م

An outstanding share, I simply offered this onto an associate who was doing a little evaluation on this. As well as he actually bought me morning meal because I found it for him. smile. So let me reword that: Thnx for the reward! Yet yeah Thnkx for investing the time to review this, I really feel highly about it as well as love finding out more on this subject. Ideally, as you come to be knowledge, would certainly you mind upgrading your blog with more information? It is extremely practical for me. Large thumb up for this blog post!

https://cannabidioloilfordogs.com/

Reply
benefits of cbd oil 18 يوليو، 2020 - 5:54 ص

Great blog post. I discover something more challenging on different blogs day-to-day. It will certainly always be boosting to review material from other authors and also exercise a little something from their store. I?d favor to make use of some with the material on my blog site whether you don?t mind. Natually I?ll provide you a web link on your internet blog. Many thanks for sharing.

https://cannabidioloilfordogs.com/

Reply
what is dosage for 600 mg of cbd capsules 19 يوليو، 2020 - 4:32 ص

I am often to blogging and also i truly value your web content. The short article has actually peaks my interest. I am going to bookmark your site as well as maintain looking for brand-new info.

https://cbdpillsforsale.org/

Reply
more.. 19 يوليو، 2020 - 5:26 م

Can I just say what an alleviation to find someone who really recognizes what theyre talking about on the web. You most definitely know just how to bring an issue to light as well as make it crucial. Even more individuals need to read this and understand this side of the story. I cant believe youre not a lot more preferred since you absolutely have the present.

https://judpharmacy.com/generic/neurontin_prices.htm

Reply
over here 20 يوليو، 2020 - 12:40 م

When I initially commented I clicked the -Inform me when brand-new remarks are included- checkbox as well as now each time a remark is added I obtain 4 e-mails with the very same remark. Is there any way you can remove me from that service? Thanks!

https://judproducts.com/generic/dostinex_prices.htm

Reply
Jerry Esquea 21 يوليو، 2020 - 6:56 م

A remarkable share, I just offered this onto a coworker who was doing a little analysis on this. And also he actually acquired me morning meal due to the fact that I found it for him. smile. So let me reword that: Thnx for the treat! Yet yeah Thnkx for spending the moment to review this, I really feel strongly concerning it and also enjoy learning more on this topic. Preferably, as you end up being expertise, would you mind upgrading your blog with more information? It is extremely valuable for me. Big thumb up for this post!

http://dist-learn.ru/

Reply
visit homepage 24 يوليو، 2020 - 12:13 م

I?d need to consult you right here. Which is not something I typically do! I enjoy reading an article that will make individuals assume. Likewise, thanks for permitting me to comment!

http://luchshayaferma.ru/everything-you-need-to-know-about-ordering-medications-from-online-pharmacy-cbd-350-vv-instructions/

Reply
Our site 25 يوليو، 2020 - 2:32 م

There is noticeably a package to know about this. I presume you ensured wonderful factors in attributes additionally.

http://excellenter.ru/10-hints-to-buy-the-best-mattress-for-back-pain/

Reply
discover more here 29 يوليو، 2020 - 10:18 م

There are certainly a great deal of details like that to consider. That is a terrific point to bring up. I use the ideas over as basic inspiration however plainly there are questions like the one you raise where one of the most essential point will be operating in straightforward good faith. I don?t understand if best methods have actually arised around points like that, yet I make sure that your job is clearly recognized as a fair game. Both kids and girls feel the impact of simply a moment?s pleasure, for the rest of their lives.

http://sibecopalata.ru/

Reply
안전 메이저사이트 30 يوليو، 2020 - 8:19 م Reply
Google 31 يوليو، 2020 - 12:18 ص

Great information. Lucky me I came across your blog by chance (stumbleupon). I have book-marked it for later!

https://google.com

Reply
안전사이트 31 يوليو، 2020 - 5:12 ص

Best view in the town !

https://kizi-2.org

Reply
안전사이트 31 يوليو، 2020 - 8:24 م Reply
cougar phone sex 2 أغسطس، 2020 - 4:10 ص

What’s up friends, its fantastic article regarding educationand entirely explained, keep it up all the time.

https://www.landpage.co/c9ad11cc-c83c-11ea-8c4c-def777a16ebd

Reply
안전토토 2 أغسطس، 2020 - 4:51 ص

Best view in the town !

https://warrantnavi.net

Reply
안전해외사이트 2 أغسطس، 2020 - 4:30 م

Love watching movies !

https://tripleshottuesday.com

Reply
안전 메이저사이트 3 أغسطس، 2020 - 5:35 ص

Love watching movies !

https://kizi-2.org

Reply
안전사이트 3 أغسطس، 2020 - 6:10 ص

Best view in the town !

https://www.tranquilkneads.org

Reply
Full Article 3 أغسطس، 2020 - 11:58 ص

extremely wonderful message, i absolutely enjoy this web site, keep on it

http://psibazis.ru/how-to-seek-out-the-suitable-mattress-to-your-particular-product-service/

Reply
check my blog 4 أغسطس، 2020 - 1:40 ص

You must take part in a contest for one of the very best blog sites on the web. I will certainly suggest this site!

http://litstart.ru/category/nutra/

Reply
get more information 5 أغسطس، 2020 - 10:49 ص

Would certainly you be fascinated in trading web links?

http://expert-kuragino.ru/7-tricks-to-acquire-the-best-mattress-for-back-pain/

Reply
Las Vegas 6 أغسطس، 2020 - 6:31 ص

Do you have a spam problem on this blog; I also am a blogger, and I was wondering your situation; many of us have developed some nice procedures and we are looking to swap strategies with others, please shoot me an e-mail if interested.

https://youtu.be/f4Sa8t2b-H8

Reply
screens for security doors 6 أغسطس، 2020 - 3:05 م

Howdy, i read your blog from time to time and i own a similar one and i was just wondering if you get a lot of spam responses? If so how do you protect against it, any plugin or anything you can advise? I get so much lately it’s driving me mad so any assistance is very much appreciated.

https://youtu.be/MEnTSuDaSRU

Reply
can you buy hemp cbd oil online 7 أغسطس، 2020 - 12:02 م

Aw, this was an actually good blog post. In suggestion I would like to place in creating similar to this in addition? taking some time and real effort to make a very good write-up? yet what can I claim? I postpone alot and also never appear to get something done.

https://cbdoilcompanies.com/

Reply
proper way to take cbd oil 9 أغسطس، 2020 - 3:42 م

really wonderful post, i certainly enjoy this site, continue it

https://blurpalicious.com/

Reply
sexting 9 أغسطس، 2020 - 11:50 م

certainly like your web-site but you have to check the spelling on quite a few of your posts. Many of them are rife with spelling issues and I in finding it very troublesome to tell the reality on the other hand I’ll surely come again again.

https://is.gd/9UFtiK

Reply
Isaac Chauncey 10 أغسطس، 2020 - 8:38 ص

Can I simply say what a relief to locate someone who actually understands what theyre speaking about online. You certainly understand how to bring a concern to light and make it vital. Even more individuals require to read this as well as recognize this side of the story. I angle think youre not more preferred since you definitely have the gift.

http://10samih.ru/

Reply
does viagra really work for 70 year old man 14 أغسطس، 2020 - 2:55 م

Good post. I find out something much more tough on various blogs everyday. It will certainly always be boosting to review material from other authors as well as exercise a little something from their store. I?d choose to use some with the web content on my blog site whether you don?t mind. Natually I?ll provide you a link on your internet blog. Many thanks for sharing.

https://judpharmacy.com/

Reply
problemas de tomar muvho viagra 17 أغسطس، 2020 - 12:17 ص

This really addressed my problem, thanks!

https://judshop.com/

Reply
Google 17 أغسطس، 2020 - 9:51 ص

This is a topic which is close to my heart… Thank you! Where are your contact details though?

https://google.com

Reply
viagra mexico pharmacy 18 أغسطس، 2020 - 3:35 م

There is significantly a package to learn about this. I assume you ensured wonderful points in attributes additionally.

https://jud10.org/

Reply
how to order viagra from mexico 19 أغسطس، 2020 - 3:53 ص

The following time I review a blog, I wish that it doesn’t disappoint me as long as this set. I suggest, I know it was my selection to read, however I in fact believed youd have something interesting to claim. All I hear is a number of whining regarding something that you can deal with if you werent too hectic trying to find interest.

https://viagrawithoutadoctorprescription.com/

Reply
viagra for sale cheap 20 أغسطس، 2020 - 6:43 ص

Spot on with this review, I absolutely believe this internet site requires far more consideration. I?ll possibly be once again to check out far more, thanks for that info.

https://judpharm.com/

Reply
chewable viagra soft tabs 21 أغسطس، 2020 - 2:35 م

An intriguing conversation is worth remark. I believe that you must create a lot more on this topic, it might not be a taboo topic yet usually people are inadequate to talk on such topics. To the next. Thanks

https://noprescriptionproducts.com/

Reply
social media marketing in mangalore 25 أغسطس، 2020 - 7:57 ص

Hi there! I just wanted to ask if you ever have any issues with hackers? My last blog (wordpress) was hacked and I ended up losing many months of hard work due to no data backup. Do you have any solutions to protect against hackers?

https://growfastcomputing.com

Reply
digital marketing in mangalore 25 أغسطس، 2020 - 5:31 م

Hey! I realize this is kind of off-topic but I had to ask. Does managing a well-established blog like yours require a massive amount work? I’m brand new to operating a blog however I do write in my diary everyday. I’d like to start a blog so I can easily share my personal experience and views online. Please let me know if you have any suggestions or tips for new aspiring blog owners. Thankyou!

https://growfastcomputing.com

Reply
cbd oil legal in ny 26 أغسطس، 2020 - 3:34 م

Can I just state what an alleviation to find somebody who really recognizes what theyre discussing on the net. You most definitely know how to bring a problem to light and also make it essential. Even more individuals require to read this as well as comprehend this side of the tale. I angle believe youre not much more preferred since you most definitely have the present.

https://blurpalicious.com/

Reply
cbd oil fort myers 27 أغسطس، 2020 - 3:13 م

There are certainly a lot of information like that to think about. That is an excellent indicate raise. I use the ideas above as basic ideas however clearly there are concerns like the one you bring up where the most crucial thing will certainly be working in sincere good faith. I don?t understand if finest techniques have actually emerged around things like that, but I make certain that your work is clearly recognized as an up for grabs. Both children as well as women really feel the impact of simply a moment?s enjoyment, for the remainder of their lives.

https://cbdoil4u.org/

Reply
how long after taking cbd oil can i eat 27 أغسطس، 2020 - 11:30 م

Can I just say what a relief to discover a person that in fact recognizes what theyre talking about online. You definitely recognize exactly how to bring a problem to light and also make it crucial. More individuals need to read this and recognize this side of the story. I angle believe youre not a lot more preferred since you absolutely have the gift.

https://cannabiseducationcentre.com/

Reply
Boss Security Screens 3 سبتمبر، 2020 - 1:45 م

I’m really enjoying the design and layout of your site. It’s a very easy on the eyes which makes it much more enjoyable for me to come here and visit more often. Did you hire out a developer to create your theme? Superb work!

https://bosssecurityscreens.com/

Reply
cbd oil 5 سبتمبر، 2020 - 4:48 ص Reply
best deals on cialis 9 سبتمبر، 2020 - 12:32 م

you have a terrific blog here! would certainly you such as to make some invite posts on my blog?

https://chrxproducts.com/

Reply
magnus masticable sildenafil 10 سبتمبر، 2020 - 9:43 م

I uncovered your blog site on google as well as examine a few of your early articles. Continue to keep up the excellent run. I simply extra up your RSS feed to my MSN Information Visitor. Looking for ahead to learning more from you in the future!?

https://stablepharmacy.com/

Reply
sildenafil dosierung 14 سبتمبر، 2020 - 5:46 ص

The following time I check out a blog, I really hope that it does not disappoint me as much as this. I indicate, I recognize it was my choice to read, yet I actually believed youd have something intriguing to state. All I hear is a bunch of yawping regarding something that you could deal with if you werent too busy looking for interest.

https://fortunegraphite.com/

Reply
buy sildenafil citrate 15 سبتمبر، 2020 - 1:36 ص

This is the ideal blog for anybody who intends to learn about this subject. You recognize so much its almost difficult to argue with you (not that I really would want?HaHa). You definitely put a brand-new spin on a topic thats been blogged about for several years. Terrific things, just terrific!

https://tevaviagra.com/

Reply
best way to take sildenafil 16 سبتمبر، 2020 - 12:18 ص

I?m pleased, I should say. Truly rarely do I come across a blog that?s both informative and also entertaining, and also let me tell you, you have actually hit the nail on the head. Your suggestion is outstanding; the problem is something that not enough people are talking wisely around. I am really happy that I came across this in my search for something connecting to this.

https://upharmacy24.com/

Reply
what is sildenafil 100mg 17 سبتمبر، 2020 - 4:16 ص

Aw, this was a really good blog post. In suggestion I would love to place in writing such as this furthermore? taking some time and also real effort to make an excellent article? but what can I say? I postpone alot and never appear to get something done.

https://cheapgenericpills.com/

Reply
non prescription drugs for erectile dysfunction 18 سبتمبر، 2020 - 9:56 ص

There are absolutely a lot of details like that to take into account. That is a great indicate raise. I supply the ideas over as general inspiration but plainly there are concerns like the one you raise where one of the most important point will be operating in truthful good faith. I don?t know if finest methods have actually arised around points like that, yet I make sure that your task is plainly identified as a fair game. Both young boys as well as women feel the impact of just a moment?s enjoyment, for the remainder of their lives.

https://pharmacywithoutdoctorprescription.com/

Reply
cbd gummy for sale 21 سبتمبر، 2020 - 3:22 م

This really addressed my trouble, thanks!

https://cbdhempoilsale.us/

Reply
Scottie Fitzgerrel 29 سبتمبر، 2020 - 3:04 ص

really great article, i absolutely like this website, go on it

http://koch-shop.ru/

Reply
cbd websites for sale 30 سبتمبر، 2020 - 4:10 ص

Your location is valueble for me. Many thanks !?

https://cannabidioloilsale.com/

Reply
dentafix 30 سبتمبر، 2020 - 9:26 م

I’m not that much of a online reader to be honest but your sites really nice, keep it up! I’ll go ahead and bookmark your website to come back later. Many thanks

http://maps.google.co.kr/url?q=https://www.google.com/maps?cid=4475027198637780466

Reply
complete dental care 1 أكتوبر، 2020 - 4:21 ص

Greetings from Idaho! I’m bored at work so I decided to check out your blog on my iphone during lunch break. I enjoy the info you provide here and can’t wait to take a look when I get home. I’m surprised at how fast your blog loaded on my phone .. I’m not even using WIFI, just 3G .. Anyhow, fantastic site!

https://maps.google.nl/url?q=https://www.google.com/maps?cid=4475027198637780466

Reply
family dental practice 2 أكتوبر، 2020 - 10:41 ص

Do you have a spam problem on this site; I also am a blogger, and I was wondering your situation; we have developed some nice procedures and we are looking to swap methods with others, please shoot me an e-mail if interested.

https://nutritiondata.self.com/facts/recipe/1304991/2?mbid=HDFD&trackback=https://sites.google.com/site/affordabledentistinannapolismd/

Reply
dental medical 2 أكتوبر، 2020 - 6:45 م

Hey! Someone in my Facebook group shared this site with us so I came to take a look. I’m definitely enjoying the information. I’m bookmarking and will be tweeting this to my followers! Terrific blog and amazing style and design.

http://www.eurohockey.com/multimedia/photo/1388-2016-pan-american-tournament.html.html?url_back=http://www.jackiejonesdmd.com

Reply
rotten teeth 4 أكتوبر، 2020 - 5:58 م

Amazing blog! Is your theme custom made or did you download it from somewhere? A theme like yours with a few simple tweeks would really make my blog stand out. Please let me know where you got your theme. Kudos

http://www.ci.pittsburg.ca.us/redirect.aspx?url=https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS83OTUyOTAucnNz

Reply
e max 4 أكتوبر، 2020 - 6:01 م

Hey! Do you know if they make any plugins to assist with SEO? I’m trying to get my blog to rank for some targeted keywords but I’m not seeing very good success. If you know of any please share. Thank you!

https://register.aib.gov.uk/Subscribe/WidgetSignup?url=https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS85OTI3NDkucnNz

Reply
ismile 4 أكتوبر، 2020 - 6:06 م

I’m really enjoying the theme/design of your weblog. Do you ever run into any web browser compatibility issues? A handful of my blog audience have complained about my blog not working correctly in Explorer but looks great in Opera. Do you have any solutions to help fix this problem?

https://google.com.pk/url?q=https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS83OTUyOTAucnNz

Reply
Jeffrey Zerr 7 أكتوبر، 2020 - 12:40 ص

Awesome blog! Is your theme custom made or did you download it from somewhere? A design like yours with a few simple tweeks would really make my blog shine. Please let me know where you got your design. Thanks a lot

https://justpaste.it/44lo7

Reply
Lisbeth Melbye 7 أكتوبر، 2020 - 3:14 م

Hi, your blog is full of comments and it is very active,  

https://papaly.com/categories/share?id=d00818195e92410287f01e15a70358a9

Reply
Hung Tolchin 7 أكتوبر، 2020 - 11:54 م

Thank you for the good writeup. It in fact used to be a enjoyment account it. Look complicated to far brought agreeable from you! However, how can we keep up a correspondence?

https://itsmyurls.com/outbound/5d9cba89e2ca27d60b7ec358

Reply
Magaret Munise 8 أكتوبر، 2020 - 4:28 م

Aw, this was an extremely good post. In concept I have to devote writing this way additionally – taking time and actual effort to make a good article… but what / things I say… I procrastinate alot and by no means often get something accomplished.

https://trello.com/c/sSzhPoCZ

Reply
cbd oil dog cornell 16 أكتوبر، 2020 - 7:45 ص

Aw, this was a really great article. In concept I would love to place in composing like this in addition? taking time as well as real effort to make a great write-up? but what can I say? I procrastinate alot as well as by no means seem to get something done.

https://cbdoilfordog.org/

Reply
cbd oil for chronic pain 17 أكتوبر، 2020 - 3:04 ص

I am commonly to blogging as well as i truly value your material. The article has truly peaks my interest. I am mosting likely to bookmark your site as well as maintain checking for brand-new information.

https://cannabidiolnopain.com/

Reply
security screens 22 أكتوبر، 2020 - 7:59 م

Thanks for your marvelous posting! I genuinely enjoyed reading it, you happen to be a great author.I will be sure to bookmark your blog and definitely will come back down the road. I want to encourage continue your great work, have a nice afternoon!

https://news3lv.com/news/videos/boss-security-screens-speaks-bout-how-to-protect-your-home-from-break-ins

Reply
weed growing machine 24 أكتوبر، 2020 - 7:00 ص

Right now it looks like Drupal is the best blogging platform available right now. (from what I’ve read) Is that what you’re using on your blog?

https://homegrowncannabisco.community/

Reply
Charmain Siddiq 27 أكتوبر، 2020 - 7:06 م

It?s difficult to find knowledgeable individuals on this subject, yet you sound like you know what you?re discussing! Many thanks

http://stal-dndz.ru/

Reply
rubber slip joint washer 6 نوفمبر، 2020 - 8:15 ص

Interesting blog! Is your theme custom made or did you download it from somewhere? A theme like yours with a few simple tweeks would really make my blog stand out. Please let me know where you got your design. Bless you

https://storage.googleapis.com/flatwashers/rubber.html

Reply
security screens price 7 نوفمبر، 2020 - 3:24 م

Do you have a spam issue on this site; I also am a blogger, and I was wondering your situation; many of us have developed some nice procedures and we are looking to swap methods with other folks, be sure to shoot me an e-mail if interested.

https://blogs.cornell.edu/react/2018/04/02/inside-the-mind-of-a-burglar/

Reply
where is cbd oil illegal 9 نوفمبر، 2020 - 9:55 ص

I?d have to check with you below. Which is not something I generally do! I take pleasure in reading a post that will make people assume. Additionally, thanks for permitting me to comment!

https://cdboilstore.com/

Reply
canada pharmacy online 12 نوفمبر، 2020 - 8:01 م

pharmacy in canada medications

http://supermarketpharmacysummit.com/

Reply
best canadian mail order pharmacies 11 ديسمبر، 2020 - 3:20 ص

I?d have to check with you here. Which is not something I usually do! I delight in reviewing a post that will make individuals assume. Additionally, thanks for permitting me to comment!

http://supermarketpharmacysummit.com/

Reply
blue chew viagra scam godoctorofff 15 ديسمبر، 2020 - 7:48 م

you have a wonderful blog below! would certainly you like to make some invite blog posts on my blog site?

http://judshop.com/

Reply
what kind of doctor to go to get viagra 16 ديسمبر، 2020 - 7:05 م

very good blog post, i definitely love this internet site, go on it

https://jud10.org/

Reply
cbd oil 500mg 18 ديسمبر، 2020 - 10:25 ص

I uncovered your blog site on google and inspect a few of your early blog posts. Remain to maintain the excellent operate. I simply added up your RSS feed to my MSN News Visitor. Seeking onward to learning more from you later on!?

http://cannabisoil24.com/

Reply
cialis without a doctor prescription canada 19 ديسمبر، 2020 - 5:02 م

Your area is valueble for me. Thanks !?

http://cialispharm.com/

Reply
cialis over the counter cvs 20 ديسمبر، 2020 - 9:55 ص

This is the right blog site for any person who wants to find out about this subject. You recognize a lot its almost hard to suggest with you (not that I in fact would want?HaHa). You most definitely put a new spin on a topic thats been covered for several years. Excellent things, just great!

http://chrxproducts.com/

Reply
is cialis generic available 21 ديسمبر، 2020 - 4:09 م

Can I simply state what a relief to locate somebody who really recognizes what theyre discussing on the web. You certainly know how to bring a problem to light and make it vital. More individuals require to read this and comprehend this side of the story. I angle think youre not a lot more preferred because you absolutely have the gift.

http://cheapgenericpharmacy.org/

Reply
arthritis and prednisone treatment 22 ديسمبر، 2020 - 3:19 م

I?m satisfied, I need to say. Really hardly ever do I experience a blog that?s both educative as well as amusing, and let me tell you, you have actually hit the nail on the head. Your idea is superior; the issue is something that insufficient individuals are speaking intelligently about. I am extremely pleased that I came across this in my search for something associating with this.

https://judpharma.com/zz240497.htm

Reply
vardenafil compared to tadalafil 23 ديسمبر، 2020 - 2:50 م

Oh my goodness! an impressive write-up guy. Thank you Nonetheless I am experiencing issue with ur rss. Don?t know why Unable to subscribe to it. Exists any individual obtaining the same rss trouble? Any person that understands kindly respond. Thnkx

https://usorganicpharmacy.com/

Reply
non prescribed viagra 24 ديسمبر، 2020 - 12:40 م

Oh my goodness! an incredible short article man. Thanks Nevertheless I am experiencing problem with ur rss. Don?t understand why Unable to sign up for it. Is there anyone getting similar rss trouble? Any individual that knows kindly respond. Thnkx

https://judproducts.com/

Reply
viagra 100mg street value 24 ديسمبر، 2020 - 11:29 م

Oh my goodness! an outstanding article dude. Thank you Nonetheless I am experiencing concern with ur rss. Don?t recognize why Incapable to sign up for it. Is there any person obtaining identical rss issue? Any person that understands kindly react. Thnkx

https://judpharmacy.com/

Reply
que es mejor viagra o cialis 26 ديسمبر، 2020 - 4:52 م

I?m satisfied, I need to claim. Really seldom do I encounter a blog site that?s both instructional and amusing, as well as let me tell you, you have struck the nail on the head. Your suggestion is superior; the problem is something that not nearly enough individuals are talking wisely about. I am extremely happy that I stumbled across this in my search for something relating to this.

https://judrxstore.com/

Reply
sildenafil 100mg price from aum.pharmacy 26 ديسمبر، 2020 - 11:58 م

This web site is really a walk-through for every one of the information you wanted regarding this and didn?t understand that to ask. Look here, as well as you?ll definitely discover it.

https://fortunegraphite.com/

Reply
sildenafil iv to po conversion 28 ديسمبر، 2020 - 3:05 م

This website is actually a walk-through for every one of the information you wanted regarding this and also didn?t know that to ask. Glance here, as well as you?ll definitely uncover it.

https://tevaviagra.com/

Reply
sildenafil standard of care 29 ديسمبر، 2020 - 2:27 ص

The next time I review a blog site, I really hope that it does not dissatisfy me as high as this. I mean, I understand it was my selection to check out, but I in fact thought youd have something fascinating to claim. All I hear is a lot of whimpering regarding something that you can take care of if you werent too busy seeking interest.

https://upharmacy24.com/

Reply
sildenafil 100mg tablets for sale 31 ديسمبر، 2020 - 11:29 ص

you have an excellent blog site here! would you such as to make some invite articles on my blog site?

https://cheapgenericpills.com/

Reply
best THC gummies 2 يوليو، 2021 - 10:15 ص Reply

Leave a Comment

Editor-in-Chief: Nabil El-bkaili

CANADAVOICE is a free website  officially registered in NS / Canada.

 We are talking about CANADA’S international relations and their repercussions on

peace in the world.

 We care about matters related to asylum ,  refugees , immigration and their role in the development of CANADA.

We care about the economic and Culture movement and living in CANADA and the economic activity and its development in NOVA  SCOTIA and all Canadian provinces.

 CANADA VOICE is THE VOICE OF CANADA to the world

Published By : 4381689 CANADA VOICE \ EPUBLISHING \ NEWS – MEDIA WEBSITE

Tegistry id 438173 NS-HALIFAX

1013-5565 Nora Bernard str B3K 5K9  NS – Halifax  Canada

1 902 2217137 –

Email: nelbkaili@yahoo.com 

 

Editor-in-Chief : Nabil El-bkaili
-
00:00
00:00
Update Required Flash plugin
-
00:00
00:00