If you got Omicron post-vaccination, medical experts advise not to rush out for a booster shot

Don’t get a shot while sick, wait at least a month after recovering, immunologists say

Lauren Pelley · CBC News 

In just a matter of weeks, hundreds of thousands of Canadians likely became infected with the Omicron variant of the coronavirus.

The unprecedented surge of cases has led to cancelled surgeries, staffing shortages in the health-care system and record-breaking hospitalization rates — alongside plenty of less serious bouts of illness, including among those who’ve been fully vaccinated against COVID-19.

If you’re now one of a growing number of people who’ve been infected post-vaccination, you might be wondering when it’s appropriate to get a booster — or if you need one at all.

“People should still get a booster,” Dr. Lynora Saxinger, an infectious diseases specialist and associate professor at the University of Alberta in Edmonton, told CBC News. “I think the harder part is, when is the best time to boost?”

Provincial guidance on that timing varies across the country, ranging from Quebec’s suggestion to simply wait until your symptoms go away to a recommendation from Ontario’s top doctor to hold off for 30 days.

There’s no magic number, but the science behind how our immune system works means you might want to wait weeks or even months after an Omicron infection to reap the benefits of a booster shot.

Don’t get a shot while sick

In general, if you’re sick, you shouldn’t get any type of vaccine, said Alyson Kelvin, a virologist and vaccine researcher at the University of Saskatchewan’s Vaccine and Infectious Disease Organization in Saskatoon.

“Your body’s immune response to whatever it’s fighting is going to be directed toward that pathogen,” she explained.

At the same time, your body might not respond as effectively to a vaccine dose, which is meant to trigger your immune system by imitating a threat like the coronavirus. “So this is generally why we should wait some time after being infected to get any vaccine,” Kelvin said.

The ideal time to get a booster shot, she said, is when your immune system has calmed down.

Alyson Kelvin, a virologist and vaccine researcher at the University of Saskatchewan’s Vaccine and Infectious Disease Organization in Saskatoon, says it’s important to wait until virus symptoms have disappeared before getting a booster. (David Stobbe)

Kelvin likened what’s happening inside your body to the process of recruiting people for a job: You want highly trained candidates for a specific task, which in this case means fighting off the coronavirus.

“Say you send out a job advertisement, and you get lots of people responding to that job. That’s kind of like when you’re given an initial vaccine, or you’re infected, and your immune response starts to recruit all of these different immune cells,” she said.

• Quebec recommends 3rd dose for those who’ve recently had COVID-19

That’s a busy time, but the bulk of those immune cells — or job applicants, shall we say — will eventually tail off. That’s when you want another boost to re-engage the immune system, or as Kelvin’s analogy goes, another chance to regroup with applicants that are best fitted for the job.

“So definitely, you want to wait till your symptoms clear up, and probably it’s beneficial to wait an extra month or a couple of weeks after your initial infection, as you’ll have more benefits of that boost,” she said.

No need to rush getting a booster post-infection

Other immunologists agreed there’s really no urgent need for a booster post-infection.

“I think it’s a better idea to wait several months before getting boosted because then the boost will be more effective,” said Dr. Jamie Scott, a molecular immunologist and professor emeritus at Simon Fraser University in Burnaby, B.C. “It’ll have a stronger effect again because the memory cells will be much more fully developed and the antibody levels will be down.”

• Booster barriers: Vulnerable groups in Ontario still struggling to get 3rd dose of COVID-19 vaccine

“I don’t think it makes a lot of sense to get a booster soon after you’ve recovered from an Omicron infection,” echoed Deepta Bhattacharya, a professor of immunobiology at the University of Arizona in Tucson.

Preliminary data suggests infections with this variant also protect against getting infected by the once-dominant Delta variant, he said, which reduces your chance of being infected with either version of the virus right away.

And Bhattacharya noted that not rushing out and getting a booster soon after your recovery actually aligns with Canada’s unorthodox vaccination approach — to space out doses — throughout the pandemic.

In just a matter of weeks, hundreds of thousands of Canadians likely became infected with the Omicron variant. (Chris Young/The Canadian Press)

Canada known for spacing out doses

Before vaccine shipments started ramping up, Canada’s National Advisory Committee on Immunization issued a bold recommendation to delay second doses well beyond manufacturing guidelines to a maximum of four months.

While the move was controversial at the time, vaccine experts had told CBC News it was rooted in decades of vaccine science and could actually provide more protection than sticking to the tight schedule of clinical trials.

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“One of the things Canada has taught us is spacing them out — spacing out your exposures — makes a big difference in the quality and the magnitude of antibodies that you get,” Bhattacharya said.

The next phase in protecting people from Omicron and future variants may require developing vaccines tailored to those threats.

“Right now, the boosters that we have are matched to a strain that’s long gone — and probably never will be seen again,” he said. “So my hope is we’ll get some better options down the road.”